Sangwoo Park

Dec 19, 2024 | nature.com | Sangwoo Park |Marcela V. Maus |Bryan Choi

Treatment for malignant primary brain tumors, including glioblastoma, remains a significant challenge despite advances in therapy. CAR-T cell immunotherapy represents a promising alternative to conventional treatments. This review discusses the landscape of clinical trials for CAR-T cell therapy targeting brain tumors, highlighting key advancements like novel target antigens and combinatorial strategies designed to address tumor heterogeneity and immunosuppression, with the goal of improving outcomes for patients with these aggressive cancers.

Mar 28, 2024 | biorxiv.org | Sangwoo Park

AbstractMost protein molecules exist in a water medium and interact with numerous water molecules. Consideration of interactions between protein molecules and water molecules is essential to understanding the functions of the protein. In computational studies on protein functions, either implicit solvation or explicit solvation methods are used to consider the effect of water on the protein.