SANTOSH KUMAR GUPTA

2 weeks ago | tandfonline.com | SANTOSH KUMAR GUPTA |Devesh Kumar

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Feb 21, 2024 | scienceopen.com | SANTOSH KUMAR GUPTA |Luisa Fernández |David Bourdon |Ernest T Lam

As treatment options expand for metastatic colorectal cancer (mCRC), a blood marker with a prognostic and predictive role could guide treatment. We tested the hypothesis that circulating tumor cells (CTCs) could predict clinical outcome in patients with mCRC. In a prospective multicenter study, CTCs were enumerated in the peripheral blood of 430 patients with mCRC at baseline and after starting first-, second-, or third-line therapy. CTCs were measured using an immunomagnetic separation technique.