Sara Conde-Berriozabal

May 3, 2023 | jneurosci.org | Sara Conde-Berriozabal |Esther García-García |Xavier López-Gil |Emma Muñoz-Moreno

DiscussionCortical premotor areas are prominently affected in HD many years before the onset of motor symptoms. These alterations have been widely correlated to cortico-striatal disconnection and associated to motor deficits, which are severely manifested in HD. Here, we thoroughly mapped M2 cortex connectivity in HD mice and described prominent structural and functional defects, particularly in the M2 cortex projection to the SC.