Sara Lambrichts

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Vascular contribution to cognitive impairment in heart failure with preserved ejection fraction: TRPV4 and KLF2 as key mediators of neurovascular dysfunction in the ZSF1 model

Jan 12, 2025 | biorxiv.org | Sara Lambrichts |Irene Pastor |Nicole Bitsch |Peter Leenders

AbstractBackground The development of vascular cognitive impairment (VCI) and heart failure with preserved ejection fraction (HFpEF) are strongly associated with comorbidities such as obesity, diabetes, hypertension, and aging. Microvascular dysfunction may be key a pathological step in the development of cognitive dysfunction during HFpEF.

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