Sara Montserrat-Vazquez

2 months ago | biorxiv.org | Eva Mejía-Ramírez |Barbara F. Walter |Sara Montserrat-Vazquez |Pablo Ianez-Picazo

AbstractBiomechanical alterations contribute to the decreased regenerative capacity of hematopoietic stem cells (HSCs) upon aging. RhoA is a key regulator of mechano-signaling but its role for mechanotransduction in stem cell aging has not been investigated yet. Here, we show that murine HSCs respond to increased nuclear envelope (NE) tension by inducing NE translocation of P-cPLA2, which cell intrinsically activates RhoA.