Satheesh Sengodan

Apr 1, 2024 | jci.org | Neil Johnson |Satheesh Sengodan |Subhajyoti De |Shyam K. Sharan

AbstractWhile breast cancer 2 (BRCA2) loss of heterozygosity (LOH) promotes cancer initiation, it can also induce death in nontransformed cells. In contrast, mismatch repair gene mutL homolog 1 (MLH1) is a tumor-suppressor gene that protects cells from cancer development through repairing mismatched base pairs during DNA mismatch repair (MMR).