Scott Laughlin

Jul 31, 2024 | pubs.rsc.org | Wei Huang |Kangqiao Wen |Scott Laughlin |Jorge Escorihuela

Unveiling the Reactivity of 2H‑(Thio)pyran-2-(thi)ones in Cycloaddition Reactions with Strained Alkynes through Density Functional Theory Studies We have theoretically investigated the inverse electron demand Diels–Alder reaction of endo-bicyclo[6.1.0]nonyne (endo-BCN) with 2H-pyran-2-one, 2H-thiopyran-2-one, 2H-pyran-2-thione and 2H-thiopyran-2-thione. These 2H‑(thio)pyran-2-(thi)ones have displayed different reactivity towards endo-BCN.

Oct 13, 2023 | cell.com | Stony Brook |Scott Laughlin

SummaryIn classic bioorthogonal labeling experiments, the cell’s biosynthetic machinery incorporates bioorthogonal tags, creating tagged biomolecules that are subsequently reacted with a corresponding bioorthogonal partner. This two-step approach labels biomolecules throughout the organism indiscriminate of cell type, which can produce background in applications focused on specific cell populations.

Oct 13, 2023 | cell.com | Wei Huang |Stony Brook |Scott Laughlin

Sletten E.M. Bertozzi C.R. Bioorthogonal chemistry: Fishing for selectivity in a sea of functionality. Angew. Chem. Int. Ed. 2009; 48: 6974-6998https://doi.org/10.1002/anie.200900942Scinto S.L. Bilodeau D.A. Hincapie R. Lee W. Nguyen S.S. Xu M. am Ende C.W. Finn M.G. Lang K. Lin Q. et al. Bioorthogonal chemistry. Nat. Rev. Methods Primers. 2021; 1: 30https://doi.org/10.1038/s43586-021-00028-zSmeenk M.L.W.J. Agramunt J. Bonger K.M. Recent developments in bioorthogonal chemistry and the orthogonality within.

Jun 18, 2023 | biorxiv.org | Scott Laughlin