Scuola Superiore Sant’Anna

Nov 5, 2024 | academic.oup.com | Scuola Superiore Sant’Anna

Heart failure (HF) is characterized by autonomic nervous system (ANS) imbalance and low-grade chronic inflammation. The bidirectional relationship between the ANS and immune system (IS) is named “neuroimmune cross-talk” (NICT), and is based on common signaling molecules, receptors, and pathways. NICT may be altered in HF, and neuroinflammation seems to be a main driver of HF progression.

Nov 2, 2024 | academic.oup.com | Scuola Superiore Sant’Anna

This paper examines the extent to which patent litigiousness relates to entry into a new technological domain (TD). Unless firms have sufficient intellectual property (IP) capabilities, patent litigiousness in the form of opposition may raise barriers to entry. We test this hypothesis using a large-scale dataset of patents applied for at the European Patent Office (EPO) between 2000 and 2015. We introduce a new measure of TD patent litigiousness based on the frequency of oppositions at the EPO.

Oct 28, 2024 | journals.plos.org | Silvestro Micera |Bioelectronics Area |Scuola Superiore Sant’Anna |Guglielmo Foffani

Neurotechnology is rapidly evolving from its origins in basic brain mapping and diagnostic tools into an innovative field with real, transformative clinical applications. Recent advancements have made neurotechnology more clinically viable, allowing for effective treatment and rehabilitation options for various neurological and psychiatric disorders.

Sep 23, 2024 | academic.oup.com | Scuola Superiore Sant’Anna

Central (CA) and obstructive apneas (OA) are highly prevalent in patients with chronic heart failure (HF) and transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized HF etiology. This study aimed to investigate the prevalence and impact of CA and OA in patients with ATTR-CA. Consecutive patients with ATTR-CA underwent a 24-hour ambulatory cardiorespiratory monitoring to evaluate the prevalence and severity of breathing disorders.

Jul 5, 2024 | link.springer.com | Scuola Superiore Sant’Anna

AbstractImplantable vagus nerve stimulation is a promising approach for restoring autonomic cardiovascular functions after heart transplantation. For successful treatment a system should have multiple electrodes to deliver precise stimulation and complex neuromodulation patterns. This paper presents an implantable multi-channel stimulation system for vagal-cardiac neuromodulation studies in swine species.