Sean Anderson

Dec 1, 2024 | medium.com | Sean Anderson

Sean Anderson·Follow6 min read·--What is Multicollinearity? Multicollinearity occurs in linear regression when independent variables (predictors) show a high degree of linear correlation with oneanother. [1]In a nutshell, multicollinearity means that some features are correlated and able to explain another feature changes. Let’s look at the provided example below for easier understanding.

May 17, 2023 | science.org | Ernest Moles |Sean Anderson |Tanes I. Lima |Saravanan Raju

AbstractChikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes epidemics of acute and chronic musculoskeletal disease. Here, we analyzed the human B cell response to a CHIKV-like particle–adjuvanted vaccine (PXVX0317) from samples obtained from a phase 2 clinical trial in humans (NCT03483961). Immunization with PXVX0317 induced high levels of neutralizing antibody in serum against CHIKV and circulating antigen–specific B cells up to 6 months after immunization.

May 10, 2023 | science.org | Ernest Moles |Sean Anderson |Tanes I. Lima |Wei Shi

AbstractCheckpoint immunotherapy has yielded meaningful responses across many cancers but has shown modest efficacy in advanced prostate cancer. B7 homolog 3 protein (B7-H3/CD276) is an immune checkpoint molecule and has emerged as a promising therapeutic target. However, much remains to be understood regarding B7-H3’s role in cancer progression, predictive biomarkers for B7-H3–targeted therapy, and combinatorial strategies.