
Sean Brady
Reporter @KamThisWeek, photos sometimes
Articles
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Nov 20, 2024 |
nature.com | Swathi V. Iyer |David Hsieh |Xuanhua P. Xie |Sean Brady |Seán Brady
AbstractGlioblastoma is incurable and in urgent need of improved therapeutics1. Here we identify a small compound, gliocidin, that kills glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2). IMPDH2 blockade reduces intracellular guanine nucleotide levels, causing nucleotide imbalance, replication stress and tumour cell death2.
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Apr 5, 2023 |
forums.digitalspy.com | Sean Brady
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Mar 6, 2023 |
biorxiv.org | Sean Brady
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Mar 2, 2023 |
nature.com | Michael Gates |Sean Brady
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Mar 15, 2022 |
gene-watson.com | Sean Brady
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RT @dataeditor: this was the email that @elonmusk sent @drewharwell two days ago https://t.co/tqqYnxLOQa

What getting booed does to an insecure billionaire:

Journalists who cover Elon Musk have been suspended on Twitter tonight: @Donie O'Sullivan from CNN, Aaron Rupar and the Washington Post's @drewharwell. Rupar tells me he has "no idea" why it happened.

After being interrupted by protesters, TRU apparently reconvened its board of governors meeting in private: https://t.co/jTcMLRRfkf #Kamloops #myTRU