Sebastiaan Breedveld

Oct 26, 2023 | frontiersin.org | Humberto J. Rocha |James Chow |Sebastiaan Breedveld

1 IntroductionNumerical optimization methods lie at the heart of state-of-the-art inverse treatment planning for intensity-modulated radiation therapy (IMRT) (1). Usually, a clinical prescription of the treatment goals forms the input to a nonlinear multi-criteria optimization (MCO) problem with or without additional constraints, depending on the desired patient dose distribution.