Selcan Aydin

Jul 3, 2024 | biorxiv.org | Selcan Aydin |Daniel A Skelly |Dylan Stavish |Alexander Stanton

AbstractThe genetic integrity of pluripotent stem cells (PSC) is integral to their applications in research and therapy, but it is compromised by frequent development of copy number variations. Little is known about the basis of the variable genomic integrity among different PSC lines. Here we identify aneuploidies using RNA-seq and proteomics data from a panel of mouse embryonic stem cell (mESC) lines derived from 170 Diversity Outbred mice.