Sen Luo

Sep 9, 2024 | onlinelibrary.wiley.com | Sen Luo |Xi ZHOU |Meijing Wu |Gongxin Wang

1 Introduction Voltage-gated sodium (Nav) channel Nav1.7 is preferentially expressed in the peripheral nervous system and is essential for action potential (AP) generation in sensory neurons due to its role in the initial signal amplification, possibly serving as a threshold channel for APs.[1] Clinical and genetic evidence shows that Nav1.7 plays an important role in the perception of pain signals.[1, 2] Accordingly, Nav1.7 is considered as an analgesic target, and pharmacological inhibition...