Sepehr Dehghani-Ghahnaviyeh

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Ionizable Amino Lipids Distribution and Effects on DSPC/Cholesterol Membranes: Implications for Lipid Nanoparticle Structure

Feb 26, 2023 | pubs.acs.org | Sepehr Dehghani-Ghahnaviyeh |Michael Smith |Michaël Smith |Yan Xia |Athanasios Dousis

AbstractLipid nanoparticles (LNPs) containing ionizable aminolipids are among the leading platforms for the successful delivery of nucleic-acid-based therapeutics, including messenger RNA (mRNA). The two recently FDA-approved COVID-19 vaccines developed by Moderna and Pfizer/BioNTech belong to this category.

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