Sergio Villicaña

May 15, 2023 | nature.com | Damir Baranasic |Sergio Villicaña |Weihua Zhang |Borzoueh Mohammadi |Colette Christiansen |Richie Soong | +9 more

AbstractDNA methylation variations are prevalent in human obesity but evidence of a causative role in disease pathogenesis is limited. Here, we combine epigenome-wide association and integrative genomics to investigate the impact of adipocyte DNA methylation variations in human obesity. We discover extensive DNA methylation changes that are robustly associated with obesity (N = 190 samples, 691 loci in subcutaneous and 173 loci in visceral adipocytes, P < 1 × 10-7).