Sevin Adiguzel

Mar 4, 2024 | biorxiv.org | Arezoo Khosravi |Seap Sezen |Sevin Adiguzel |Atefeh Zareour

AbstractRemodeling of the extracellular matrix (ECM) eventually causes the stiffening of tumors and changes to the microenvironment. The stiffening alters the biological processes in cancer cells due to altered signaling through cell surface receptors. Autophagy, a key catabolic process in normal and cancer cells, is thought to be involved in mechano-transduction and the level of autophagy is probably stiffness-dependent.