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Shahab Saghaei

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  • Origins and diversity of pan-isotype human bone marrow plasma cells

    May 10, 2024 | biorxiv.org | Gaspar A Pacheco |Vishal Rao |Duck Kyun Yoo |Shahab Saghaei

    AbstractBone marrow plasma cells (BMPCs) produce durable, protective IgM, IgG, and IgA antibodies, and in some cases, pro-allergic IgE antibodies, but their properties and sources are unclear. We charted single BMPC transcriptional and clonal heterogeneity in food-allergic and non-allergic individuals across CD19 protein expression given its inverse correlation to BMPC longevity. Transcriptional and clonal diversity revealed distinct functional profiles.

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