Shanelle Clarke

Sep 12, 2024 | ahajournals.org | Jennifer Peterson |Shanelle Clarke |Bruce Gelb |Nadine Kasparian

Down syndrome or trisomy 21 (T21) is the most commonly occurring aneuploidy, affecting approximately 1 in 800 live births, and ≈35% to 50% of children with T21 are also affected by congenital heart disease (congenital HD).1 T21 is associated with significant physical, neurodevelopmental, psychological, and functional conditions that co‐occur and interact with congenital HD to impact overall health, functional status, and quality of life (QOL) across the lifespan.1, 2, 3 Improvements in...