Shang Su

Oct 4, 2023 | biorxiv.org | Ruihua Liu |Shang Su |Jing Xing |Ke Liu

AbstractBackgroundDisseminated tumor cells (DTCs) can enter a dormant state and cause no symptoms in cancer patients. On the other hand, the dormant DTCs can reactivate and cause metastases progression and lethal relapses. In prostate cancer (PCa), relapse can happen after curative treatments such as primary tumor removal. The impact of surgical removal on PCa dissemination and dormancy remains elusive.

Mar 26, 2023 | mdpi.com | Yawei Zhao |Shang Su |Xiaohong Li

Abstract: Simple SummaryThe impact of parathyroid hormone-related protein (PTHrP) and parathyroid hormone receptor 1 (PTH1R or PTHR1) on cancer initiation, growth, and metastasis has been extensively documented in a number of in vitro and in vivo studies. Despite these findings, the attempts to target PTHrP/PTH1R signaling in cancer therapy have not produced successful results in the clinical setting.