Shannon McCall

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Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers - npj Precision Oncology

May 30, 2024 | nature.com | Andrew Waters |Justine C. Rutter |Shannon McCall |Mariaelena Pierobon |J. Joshua Smith |Channing J. Der

AbstractAcquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produce durable treatment responses.

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