Shanxi Academy

Jan 17, 2025 | journals.plos.org | QING LI |Shanxi Academy |Tong Zhou |Yong Zhang

Loading metrics Open Access Peer-reviewedResearch Article Citation: Li Q, Li Y, Zhou T, Zhang Y, Li H, Yuan F, et al. (2025) FBXW7 metabolic reprogramming inhibits the development of colon cancer by down-regulating the activity of arginine/mToR pathways. PLoS ONE 20(1): e0317294. https://doi.org/10.1371/journal.pone.0317294Editor: Xinjun Lu, Sun Yat-Sen University, CHINAReceived: August 26, 2024; Accepted: December 24, 2024; Published: January 17, 2025Copyright: © 2025 Li et al.

Jan 13, 2025 | molecular-cancer.biomedcentral.com | Shanxi Academy

Cancer metabolism refers to the distinct and often reprogrammed metabolic processes in cancer cells, which significantly differ from those in normal cells. These alterations are crucial for supporting the rapid growth, survival, and proliferation of cancer cells by meeting their increased demands for energy, biosynthetic precursors, and redox balance.

Dec 8, 2024 | onlinelibrary.wiley.com | Shanxi Academy |Yang Liu |Bao Chai |Anhong Zhang

DEG differentially expressed genes DT double tryptophan HCC hepatocellular carcinoma KLF7 Krüppel-like factor 7 RNA-seq RNA sequencing SLC1A5 solute carrier family 1 member 5 SLC7A5 solute carrier family 7 member 5 TDO2 Trp 2,3-dioxygenase TPH1 Trp hydroxylase 1 Trp Tryptophan 5-HT 5-hydroxytryptamine 5-HTP L-5-hydroxytryptophan 1 Introduction Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and is often associated with chronic liver disease and cirrhosis [1,...

Dec 4, 2024 | nutritionj.biomedcentral.com | Shanxi Academy

After applying a series of exclusion criteria (see Supplemental Fig. 1), a total of 2853 participants who had at least three rounds of complete dietary data were included in the cohort. In an average 9.6 ± 1.9 years of follow-up, we documented 624 new-onset hypertension. The GBTM models with three PDI trajectories, two hPDI trajectories, and four uPDI trajectories were identified as the best fit (Supplemental Table 1).

Dec 3, 2024 | arthritis-research.biomedcentral.com | Shanxi Academy

Based on a two-sample MR study, we first assessed causality between exposure (731 immune cell characteristics) and outcome (RA and AS). In addition, the mediated (two-step approach) MR study was employed to delve deeper into the mediating effects between exposure and outcome mediated by metabolites as mediators (Fig. 1). Risk factors are represented by genetic variation also called IVs in MR study.