Shaona Yi

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Ginkgolide A downregulates transient receptor potential (melastatin) 2 to protect cisplatin-induced acute kidney injury in rats through the TWEAK/Fn14 pathway: Ginkgolide A improve acute renal injury - Haiyan He, Jun Ge, Shaona Yi, Yuhong Wang, Ye Liu, Yi

Sep 15, 2023 | journals.sagepub.com | Haiyan He |Jun Ge |Yuhong Wang |Shaona Yi

IntroductionCisplatin (cis-diaminodichlorplatin (II), CP) is a highly effective chemotherapy drug for various tumor types.1–3 However, the long-term clinical application of CP results in the serious side effects (nephrotoxicity, ototoxicity, neurotoxicity, and emetogenicity. Among these side effects, nephrotoxicity is a main sequela.4 Approximately one third of patients treated with cisplatin have renal dysfunction.

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