Sharon A. Savage

Nov 29, 2024 | nature.com | Lisa J. McReynolds |Pedro Moura |Sharon A. Savage |Ann Nordgren |Maryam Rafati

AbstractPOLA2 encodes the accessory subunit of DNA polymerase α (polα)/primase, which is crucial for telomere C-strand fill-in. Incomplete fill-in of the C-rich telomeric strand after DNA replication has been proposed as a mechanism for Coats plus syndrome, a phenotype within the broader spectrum of telomere biology disorders (TBD). Coats plus syndrome has so far been associated with pathogenic variants in POT1, CTC1, and STN1.

Oct 27, 2024 | onlinelibrary.wiley.com | Sharon A. Savage |Alison A. Bertuch

Rare germline pathogenic variants (GPVs) in genes essential for telomere length maintenance (TLM) and function cause a broad spectrum of disorders. The biological consequences of these GPVs range from short or dysfunctional telomeres and reduced cellular replicative potential to long telomeres and increased cellular replicative capacity.

Feb 19, 2024 | ncnewsonline.com | Sharon A. Savage

I first discovered the inspiring story of the University of Washington men’s rowing team on an episode of “The American Experience” about “The Boys of ‘36” on PBS. Adapted from Daniel James Brown’s historically accurate, skillfully wrought American sports saga “The Boys in the Boat: Nine Americans and Their Epic Quest for Gold at the 1936 Berlin Olympics,” the book documents the team’s odyssey from malnourished, Great Depression Era youths to Olympic champions.

Sep 13, 2023 | openpr.com | Sharon A. Savage

Retired Teacher Announces U.S. Senate RunFOR IMMEDIATE RELEASEContact: Sharon M. Savage Email: [email protected] Website: www.sharonsavageforsenate.com Sharon M. Savage Announces Candidacy for U.S. SenateOscoda, Michigan - 09/13/23 - Sharon M. Savage, a dedicated public servant with an illustrious career spanning 40 years with the Warren Consolidated School District, proudly announces her candidacy as a Republican for the U.S. Senate.

Mar 9, 2023 | gmtoday.com | Sharon A. Savage

To the editor: Mayor Magnus, in his letter to city residents and business owners, stated this real fact in the first paragraph of his letter: “We are all frustrated when costs increase, and many are struggling right now with the costs of about everything; mortgage payments, rent, food, basic services, and more.” The mayor’s letter factually laid out the truth of what we all dealt with in 2022 and are still dealing with in 2023 as we struggle with even higher inflation and possible job losses...