Sheila Jacobs

New York

Contributor at Rare Disease Advisor

Featured in: Favicon

rarediseaseadvisor.com Favicon

infectiousdiseaseadvisor.com Favicon

renalandurologynews.com Favicon

pulmonologyadvisor.com Favicon

hematologyadvisor.com

Articles

Role of Antibody Classes in IgG4-RD Helps Reveal Potential Disease Targets

1 day ago | rarediseaseadvisor.com | Sheila Jacobs

In those with immunoglobulin G4-related disease (IgG4-RD), antibodies from a variety of classes play key roles in the underlying immunologic mechanisms of the disorder and in disease progression, according to findings from a review published in Rheumatology & Autoimmunity. The precise immunopathology involved in the development of IgG4-RD remains unclear.
Microbiota, Immune Host Factors Linked to Bleeding Risk in Pediatric ITP

1 week ago | hematologyadvisor.com | Sheila Jacobs

Among pediatric patients with immune thrombocytopenia (ITP), distinct bleeding phenotypes have been recognized, which vary according to gut microbiota and immune host factors. A prospective cohort study on the subject was conducted at the University of Texas Southwestern Medical Center and Children’s Health, located in Dallas, Texas, with findings published recently in the American Journal of Hematology. Following the evaluation of 38 individuals, a total of 30 patients were enrolled in the study.
Meta-Analysis Shows Benefits of Rituximab in Patients With AAV

1 week ago | rarediseaseadvisor.com | Sheila Jacobs

In patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), maintenance therapy with rituximab has demonstrated the ability to effectively reduce disease relapses, according to findings from a network meta-analysis published recently in the Journal of the College of Physicians and Surgeons Pakistan.
Quality of Umbilical Cord Blood for Transfusion Similar to That of Adult Blood

1 week ago | rarediseaseadvisor.com | Sheila Jacobs

The quality of umbilical cord blood as a source of red blood cells (RBCs) for transfusion, including in preterm or severely anemic infants with hemolytic disease of the fetus and newborn (HDFN), has been shown to be comparable with that of adult blood, according to findings from a prospective, observational study published in the Indian Journal of Hematology and Blood Transfusion.
Microbial Profiles a Potential Marker in IgG4-RD With Lacrimal Gland Tumors

1 week ago | rarediseaseadvisor.com | Sheila Jacobs

Altered microbiota composition has been observed in the tissues of patients with lacrimal gland tumors and immunoglobulin G4-related disease (IgG4-RD), according to findings from a study published recently in Biomedicines, which could aid in diagnosing these tumors. The researchers sought to identify possible variations in microbial composition across a variety of lacrimal gland lesions.
Early Diagnosis of IgG4-Related Cholangitis Is Key for Better Outcomes

1 week ago | rarediseaseadvisor.com | Sheila Jacobs

Early diagnosis of the hepatobiliary manifestation of immunoglobulin G4-related disease (IgG4-RD), known as IgG4-related cholangitis (IRC), is essential to avoid unnecessary surgery and progression to liver fibrosis/cirrhosis. In light of this, researchers conducted a structured clinical review of this rare, severe disorder. Findings from their analysis were published recently in Gastroenterology Report (Oxford). Patients with IRC are usually male (80%-85%) and aged 50 to 75 years or older.
PFS24 Can Predict Long-Term Outcomes in Patients With PCNSL

1 week ago | rarediseaseadvisor.com | Sheila Jacobs

Progression-free survival at 24 months (PFS24) is a key predictor of long-term outcomes among patients with primary central nervous system lymphoma (PCNSL), according to findings from a multicenter, retrospective study published recently in the Journal of Hematology & Oncology. Researchers obtained data from 146 patients with newly diagnosed, transplant-eligible PCNSL who had received treatment with a MATRix-like regimen at 1 of 14 hospitals in 2 different countries.
Case Study: Hemoglobin Should Be Monitored Following IVIG Therapy

1 week ago | rarediseaseadvisor.com | Sheila Jacobs

Among individuals with certain autoimmune disorders, including fetal and neonatal alloimmune thrombocytopenia (FNAIT), intravenous immunoglobulin (IVG) is often administered for the purposes of immunomodulation. IVIG treatment, however, can be associated with rare complications, such as hemolytic anemia.
Hematologic Disorders Linked to Severe Maternal Complications

1 week ago | rarediseaseadvisor.com | Sheila Jacobs

Among pregnant women, maternal near-misses and mortality have been associated with hematologic disorders, including fetal and neonatal alloimmune thrombocytopenia (FNAIT). Findings from a retrospective, descriptive study on the subject, which was conducted in Southern Thailand, were published The Journal of Obstetrics and Gynecology of India.
Early Evaluation of Cardiovascular Risk Recommended in Patients With AAV

2 weeks ago | rarediseaseadvisor.com | Sheila Jacobs

Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) should undergo regular assessments for cardiovascular risk factors early in the course of their disease, according to findings from a population-based cohort study conducted in Sweden and published in RMD Open.