Sheng-Long Ding

Apr 29, 2024 | onlinelibrary.wiley.com | Yun Sun |Sheng-Long Ding |Xiyuan Zhao |Dadi Sun

Intra-articular injection of drugs is an effective strategy for osteoarthritis (OA) treatment. However, the complex microenvironment and limited joint space result in rapid clearance of drugs. Herein, a nanogel-based strategy was proposed for prolonged drug delivery and microenvironment remodeling. Nanogel was constructed through functionalization of hyaluronic acid (HA) by amide reaction on the surface of Kartogenin (KGN)-loaded zeolitic imidazolate framework-8 (denoted as KZIF@HA).

Mar 13, 2024 | onlinelibrary.wiley.com | Wei Xiong |Zeyu Han |Sheng-Long Ding |Haoran Wang

1 Introduction Efferocytosis is a process by which phagocytes (e.g., macrophages, dendritic cells) eliminate the apoptotic cells undergone programmed death.[1] With the deep-going research, there is growing evidence that efferocytosis has decent immunomodulatory effects, which play a crucial role in tissue regeneration.