Shreya Rajachandran

Jun 3, 2024 | biorxiv.org | Melanie Evans |Shreya Rajachandran |Xin Zhang |Yanfeng Zhang

AbstractExtrachromosomal circular DNA (eccDNA) originates from linear chromosomal DNA and can be found in various human cell types including the male germline. However, the functional effects and biogenesis mechanisms of the eccDNA in the human male germline are not well understood. Here, we developed a sequencing approach to extract eccDNA sequence information and the paired transcriptome information from the same cells.