Siaresh Aziz

Dec 23, 2024 | cell.com | Anna Flury |Leen Aljayousi |Hye-Jin Park |Mohammadparsa Khakpour |Jack Mechler |Siaresh Aziz | +10 more

1Neuroscience Initiative, Advanced Science Research Center, The City University of New York (CUNY) Graduate Center, New York, NY 10031, USA 2Graduate Program in Biology, CUNY Graduate Center, New York, NY 10016, USA 3Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C4, Canada 4Graduate Program in Biochemistry, CUNY Graduate Center, New York, NY 10016, USA 5Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Michigan Medicine, Ann...

Mar 8, 2024 | biorxiv.org | Anna Flury |Hye-Jin Park |Leen Aljayousi |Siaresh Aziz

AbstractMicroglia, the brain′s primary resident immune cells, are a heterogeneous population and can assume phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer′s disease (AD), where microglia are a leading causal cell type, microglia subsets with protective functions have been well characterized. Yet, the identity of microglia subsets that drive neurodegeneration remains unresolved.