Sicong Zhang

Sep 9, 2024 | nature.com | Sicong Zhang |Robert G. Roeder

AbstractThe bromodomain and extraterminal domain (BET) family of proteins are critical chromatin readers that bind to acetylated histones through their bromodomains to activate transcription. Here, we reveal that bromodomain inhibition fails to repress oncogenic targets of estrogen receptor because of an intrinsic transcriptional mechanism.

Jul 26, 2024 | biorxiv.org | Sicong Zhang |Robert G. Roeder

AbstractThe Bromodomain and Extra-Terminal Domain (BET) family of proteins are critical chromatin readers that bind to acetylated histones through their bromodomains to activate transcription. Here, we reveal that bromodomain inhibition fails to repress oncogenic targets of estrogen receptor due to an intrinsic transcriptional mechanism.

Apr 19, 2024 | journals.plos.org | Zhiwen Wang |Shan Zhong |Sicong Zhang |Borui Zhang |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Wang Z, Zhong S, Zhang S, Zhang B, Zheng Y, Sun Y, et al. (2024) A novel and ubiquitous miRNA-involved regulatory module ensures precise phosphorylation of RNA polymerase II and proper transcription. PLoS Pathog 20(4): e1012138.