Sijian Zhang

Jun 14, 2024 | onlinelibrary.wiley.com | Yijun Shao |Sijian Zhang |Venkatesh Raman |Samir S. Patel

Introduction Heart failure (HF) is a leading cause of morbidity and mortality.1, 2 Evidence from randomized controlled trials (RCTs) provide the foundation for guideline-directed medical therapy (GDMT) for patients with HF that contributes to improving clinical outcomes.3 Post hoc analyses of data from RCTs provide important insights into risk stratification, treatment optimization, and hypothesis generation.4-14 However, patients enrolled in RCTs are often not representative of those seen in...