Silvia Schäfer

Ansbach

Editor, Westmittelfranken at Fränkische Landeszeitung

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The histone modifier KAT2A presents a selective target in a subset of well-differentiated microsatellite-stable colorectal cancers - Cell Death & Differentiation

Mar 26, 2025 | nature.com | Vida Kufrin |Silvia Schäfer |Frank Buchholz |Martin Bornhauser |Marius Bill

AbstractLysine acetyltransferase 2 A (KAT2A) plays a pivotal role in epigenetic gene regulation across various types of cancer. In colorectal cancer (CRC), increased KAT2A expression is associated with a more aggressive phenotype. Our study aims to elucidate the molecular underpinnings of KAT2A dependency in CRC and assess the consequences of KAT2A depletion.

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