Silvia Toedter

Jul 16, 2024 | biorxiv.org | Luis Brito |Eleonore Ostermann |Anna Perez |Anna Pérez |Silvia Toedter

AbstractDifferential antiviral T cell immunity in early life impacts the clinical outcome of Cytomegalovirus (CMV) infection, but the underlying mechanisms are not well understood. Here, we found delayed enrichment of early-life murine CMV-specific CD8 T cells due to a general deficiency of alpha/beta T cells. Adoptive transfer of naive adult T cells into neonates did not protect due to a blockade of CD8 but not of CD4 effector T cell differentiation.