Simon Mueller

Oct 13, 2024 | onlinelibrary.wiley.com | Simon Mueller |Jie Zhu |Oliver Brandt |Alexander A. Navarini

1. Introduction Neurofilament light chain (NfL), a cytoskeletal protein, is a promising biomarker specific to neuroaxonal injury in various diseases such as dementia, multiple sclerosis, and peripheral neuropathies [1, 2]. Pruritus (syn. itch) is defined as an unpleasant sensation evoking the urge to scratch [3]. In the skin, itch is mainly transmitted by nonmyelinated C and thinly myelinated Aδ nerve fibers [4], with C-fibers extending into the upper epidermis [5].