Simon Pan

1 month ago | 2minutemedicine.com | Simon Pan |Alex Chan

1. In patients with advanced or recurrent endometrial cancer (EC) with previous exposure to carboplatin and paclitaxel (PT), lenvatinib plus pembrolizumab was not associated with improved survival compared with re-challenge PT. Evidence Rating Level: 2 (Good) Currently, PT three times per week remains the first-line therapy for recurrent or advanced endometrial cancer.

1 month ago | 2minutemedicine.com | Simon Pan |Alex Chan

Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury1. Compared with the use of mannitol, the use of hypertonic saline (HTS) in children with traumatic brain injury (TBI) was not associated with increased survival or improved functional outcomes. Evidence Rating Level: 2 (Good)Current guidelines from the Brain Trauma Foundation recommend the use of 3% HTS in children with TBI who have developed elevated intracranial pressure (ICP).

2 months ago | 2minutemedicine.com | Simon Pan |Alex Chan

Meconium-Related Obstruction and Clinical Outcomes in Term and Preterm Infants1. Nearly 95% of cases of meconium-related obstruction (MRO) occur in the absence of cystic fibrosis or Hirschsprung disease2.

2 months ago | 2minutemedicine.com | Simon Pan |Alex Chan

1. Intraoperative esketamine infusion significantly reduced the incidence of postpartum depression (PPD) at 6 weeks post partum in women undergoing cesarean delivery. Evidence Rating Level: 1 (Excellent)PPD, which affects nearly 18% of women after delivery globally and can have major impacts on parent-child bonding, is more likely to affect women who undergo cesarean delivery compared to vaginal delivery.

2 months ago | 2minutemedicine.com | Simon Pan |Alex Chan

1. The use of high flow nasal cannula (HFNC) in patients with obesity undergoing sedated gastrointestinal endoscopy significantly reduced the incidence of hypoxia and subclinical respiratory depression. Evidence Rating Level: 1 (Excellent)Hypoxia is the most common adverse event occurring during gastrointestinal endoscopy. Patients with obesity are at an increased risk of hypoxemia owing to several factors such as poor lung and chest wall compliance.