Siobhain Mulrennan

Apr 26, 2024 | onlinelibrary.wiley.com | Khai Tâm |Michael Wallace |Siobhain Mulrennan

INTRODUCTION An 81 year old male with a history of Child-Pugh A liver cirrhosis secondary to alcohol complicated by metastatic hepatocellular carcinoma(HCC) in 2020, was treated with 3-weekly atezolizumab and bevacizumab. After 5 months, he developed sarcoid-like pulmonary reaction, with atezolizumab(immune checkpoint inhibitor) identified as the culprit. He was treated with prednisolone, resulting in improvement, and was successfully rechallenged with both atezolizumab and bevacizumab.