Sol Guerra-Ojeda

Aug 31, 2023 | mdpi.com | Sol Guerra-Ojeda |Adrian Jorda |Constanza Aldasoro |Jose Vila |José Vila

1. IntroductionIN is a peptide hormone secreted by the beta cells of the islets of Langerhans that is the most important hormone in anabolic functions regulating glucose homeostasis. In addition to its metabolic effects, its cardiovascular actions are of special relevance, among them the synthesis of nitric oxide (NO) [1], endothelin 1 (ET-1) [2], or its effects on the adrenergic system [3]. IN has vasodilatory effects that are induced by the release of endothelial NO [1].

Aug 31, 2023 | mdpi.com | Sol Guerra-Ojeda |Andrea Suarez |Andrea B. Suárez |Alicia Valls |David Verdú

1. Introduction 1.1. BackgroundHistorically, the aryl hydrocarbon receptor (AhR) is known for its function in the metabolism of xenobiotics. As we will describe, this is a very limited view of the functions of this receptor, and several studies have associated AhR activation with important pathologies such as cancer [1] or even with genetic malformations [2,3].