Sonu Subudhi

Oct 25, 2024 | biorxiv.org | Keene L. Abbott |Sonu Subudhi |Raphael Ferreira |Yetis Gultekin

AbstractCancer metastasis is a major contributor to patient morbidity and mortality, yet the factors that determine the organs where cancers can metastasize are incompletely understood. In this study, we quantify the absolute levels of over 100 nutrients available across multiple tissues in mice and investigate how this relates to the ability of breast cancer cells to grow in different organs.

Dec 24, 2023 | biorxiv.org | Keene L. Abbott |Ahmed Ali |Bradley I. Reinfeld |Sonu Subudhi

AbstractThe tumor microenvironment is a determinant of cancer progression and therapeutic efficacy, with nutrient availability playing an important role. Although it is established that the local abundance of specific nutrients defines the metabolic parameters for tumor growth, the factors guiding nutrient availability in tumor compared to normal tissue and blood remain poorly understood.