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2 days ago | 
genengnews.com | Sophia Ktori
A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has developed an innovative method known as TEVs-TTN, for studying the specific mechanical functions of proteins through their controlled cleavage. This process renders the proteins unable to sense and transmit mechanical force. The study, headed by Jorge Alegre-Cebollada, PhD, demonstrates that interrupting mechanical transmission by the protein titin precipitates muscular diseases.
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3 days ago | 
genengnews.com | Sophia Ktori
Scientists at the Institute for Basic Science (IBS) have uncovered a non-invasive method to boost the brain’s natural waste drainage system—a discovery that they suggest could open new avenues for tackling age-related neurological disorders.
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4 days ago | 
genengnews.com | Sophia Ktori
A study led by researchers at Stanford Medicine has shown that differences in blood sugar responses to certain carbohydrates depend on details of an individual’s metabolic health status, including specific metabolic conditions such as insulin resistance or beta cell dysfunction, both of which can lead to diabetes. The findings indicate that this variability in blood sugar response could lead to personalized prevention and treatment strategies for prediabetes and diabetes.
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4 days ago | 
genengnews.com | Sophia Ktori
Home Topics Cancer PD-1 Regulates CD30, Curbs T Cell Suppression in Melanoma PD-1 deficiency enhances Treg cell pro-tumor function : Lim et al.
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1 week ago | 
genengnews.com | Sophia Ktori
Home Topics Cancer “Universal” CAR-T Immunotherapy Targets Relapsed/Refractory Blood Cancers An international clinical trial led by WashU Medicine researchers shows an innovative CAR-T cell immunotherapy is promising against aggressive T cell cancers and has manageable side effects. Senior author Armin Ghobadi, MD, prepares the new “universal” CAR-T cell product for a patient’s infusion as part of a clinical trial at Siteman Cancer Center, based at Barnes-Jewish Hospital and WashU Medicine.
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1 week ago | 
genengnews.com | Sophia Ktori
Home Topics Coronavirus PEG Alternative Minimizes Immunogenicity from LNP-Based Therapies Doctor examining the Coronavirus vaccine. [Longhua Liao/Getty Images] Doctor examining the Coronavirus vaccine. [Longhua Liao/Getty Images]
A new material developed at Cornell University could significantly improve the delivery and effectiveness of mRNA vaccines by replacing a commonly used ingredient in lipid nanoparticles (LNPs) that may trigger unwanted immune responses in some people.
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1 week ago | 
genengnews.com | Sophia Ktori
Home Topics Drug Discovery Alcohol Abuse Drug May Help Reduce Cell Death Induced by Trauma Credit: Photo by Anthony Maw on Unsplash Credit: Photo by Anthony Maw on Unsplash
A drug called disulfiram (DSF), which is used to prevent alcohol abuse, may also help to interrupt the runaway cell death and inflammation that is triggered by severe trauma, according to the results of research by University of Pittsburgh School of Medicine surgeon-scientists.
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1 week ago | 
insideprecisionmedicine.com | Sophia Ktori |Kathy Vuksanaj
A common antidepressant may help boost the immune system’s ability to fight cancer, according to new research from UCLA. The study found that selective serotonin reuptake inhibitors (SSRIs) significantly improved T cell responses and reduced tumor growth in various cancer types, using both human and mouse models. Researchers also identified the serotonin transporter (SERT) as a potential new immune checkpoint target.
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1 week ago | 
genengnews.com | Sophia Ktori
Home News Synthetic Biosensor Monitors Drugs In Vivo Over Time Credit: FatCamera/Getty Images Credit: FatCamera/Getty Images
The ability to continuously monitor the molecular state of our body could be harnessed to help optimize drug delivery or enable early detection of deadly diseases like cancer.
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2 weeks ago | 
genengnews.com | Sophia Ktori
Home News First Vascularized Organoid Model of Stem Cell-Derived Pancreatic Islets Credit: NIH Credit: NIH
An international team of researchers led by Max Delbrück Center Scientific Director Professor Maike Sander, MD, has for the first time developed an organoid model of human pluripotent stem cell-derived pancreatic islets (SC-islets) with integrated vasculature.
