Spyros Lytras

1 week ago | cell.com | Jonathan Pekar |Spyros Lytras |Mahan Ghafari |Andrew Magee |Edyth Parker |Yu Wang | +13 more

Keywords molecular epidemiology sarbecoviruses virus evolution phylogeography Introduction Horseshoe bats (Rhinolophus spp.) are the main hosts of the Sarbecovirus subgenus1 (genus Betacoronavirus, family Coronaviridae) and, likely via virus transmission through transient intermediate species, were the source of SARS-CoV (referred to hereafter as SARS-CoV-1, now extinct) and SARS-CoV-2.2,3,4 Since the first emergence of SARS-CoV-1 in Guangzhou, Guangdong Province, in 2002 and SARS-CoV-2...

Sep 4, 2024 | nature.com | Spyros Lytras |Edward C. Holmes

AbstractViral glycoproteins drive membrane fusion in enveloped viruses and determine host range, tissue tropism and pathogenesis1. Despite their importance, there is a fragmentary understanding of glycoproteins within the Flaviviridae2, a large virus family that include pathogens such as hepatitis C, dengue and Zika viruses, and numerous other human, animal and emergent viruses.