Spyros Mavropoulos

Dec 1, 2024 | nature.com | Spyros Mavropoulos

AbstractAdeno-associated virus-based gene therapy is a promising avenue in heart failure treatment, but has shown limited cardiac virus uptake in humans, requiring new approaches for clinical translation. Using a Yorkshire swine ischemic heart failure model, we demonstrate significant improvement in gene uptake with temporary coronary occlusions assisted by mechanical circulatory support.

Mar 8, 2024 | physoc.onlinelibrary.wiley.com | Tomoki Sakata |Spyros Mavropoulos |Renata Mazurek |Francisco Romeo

Supporting Information Filename Description tjp15973-sup-0001-PeerReview.pdf354.2 KB Peer Review History References , , , & (2018). A pig model of myocardial infarction: Catheter-based approaches (pp. 281–294). Springer. , , , , , , , , , & (2007). Effect of no-reflow during primary percutaneous coronary intervention for acute myocardial infarction on six-month mortality. American Journal of Cardiology, 99(4), 442–445. , , , , , , , , , , & (2006).

Feb 14, 2024 | icrjournal.com | Tomoki Sakata |Spyros Mavropoulos |Steven P. Keller

At the 6th Annual A-CURE Symposium, Dr Sakata showed preclinical evidence that mechanical left ventricular (LV) unloading increases coronary perfusion of the infarct area.1 Study data suggested that mechanical LV unloading is more beneficial in post-MI patients with high diastolic pressure associated with increased LV stiffness and in those with worse cardiac contractility.1 However, there are other factors that are thought to increase coronary flow with LV unloading, including low cardiac...

Feb 14, 2024 | icrjournal.com | Spyros Mavropoulos |Tomoki Sakata |Steven P. Keller

In acute heart failure, unloading the left ventricle (LV) by percutaneous LV assist devices (pLVAD) reduces LV filling pressures and volumes, as well as cardiac workload and wall stress, which, in turn, reduces myocardial oxygen demand and increases coronary perfusion.

Feb 14, 2024 | icrjournal.com | Tomoki Sakata |Spyros Mavropoulos |Steven P. Keller

A previous study showed that mechanical preconditioning with left ventricular (LV) unloading with a mechanical circulatory support device reduces infarct size and wall stress in acute preclinical models of MI compared with primary reperfusion, despite a delay in reperfusion by 60 min.1 Another recent research study found that transvalvular unloading and delayed reperfusion preserves myocardial energy substrate utilisation and protects mitochondrial structure and function in acute MI.2 Dr...