Steen Z. Abildstrøm

Oct 8, 2023 | jacc.org | Javed Butler |Steen Z. Abildstrøm |Barry A. Borlaug |Melanie J. Davies

Introduction Patients with heart failure (HF) have been traditionally classified based on left ventricular ejection fraction (LVEF) into those with HF and reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF).1 Clinical trials have used this classification to determine eligibility; however, the criteria demarcating the 2 groups have ranged between >40%, >45%, or ≥50% for HFpEF and ≤40 or ≤35% for HFrEF, resulting in variations in definitions as well as an evidence...