Stefanie K. Wculek

2 months ago | nature.com | Stefanie K. Wculek |Pedro Berraondo

AbstractCytotoxic T cell immune responses against cancer crucially depend on the ability of a subtype of professional antigen-presenting cells termed conventional type 1 dendritic cells (cDC1s) to cross-present antigens. Cross-presentation comprises redirection of exogenous antigens taken from other cells to the major histocompatibility complex class I antigen-presenting machinery.

Jul 12, 2024 | academic.oup.com | Dimitrios Farmakis |Stefanie K. Wculek |Judith Ozkan |Giovanna Liuzzo

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Feb 7, 2024 | nature.com | Stefanie K. Wculek

AbstractDendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells that regulate adaptive immunity, including against cancer. Therefore, understanding the precise activities of DCs in tumours and patients with cancer is important. The classification of DC subsets has historically been based on ontogeny; however, single-cell analyses are now additionally revealing a diversity of functional states of DCs in cancer.