Articles

  • 1 week ago | drugdiscoverynews.com | Stephanie DeMarco

    While oncogenes are notorious for causing cancer when mutated, they are not the only genes that keep cancer alive and spreading. Cancer fitness genes don’t cause cancer, but they help cancer cells avoid death through a variety of different mechanisms including by keeping oncogenes functioning, promoting certain signaling pathways, or sustaining an immunosuppressive environment around the tumor.

  • 1 week ago | drugdiscoverynews.com | Stephanie DeMarco

    In their quest to proliferate and spread, cancer cells will do anything they can to avoid being killed. Most often they develop mechanisms to suppress attacks by their would-be killers — immune cells. One way researchers and clinicians fight back against this suppression is with cancer vaccines that help immune cells recognize and attack cancer cells. But recognizing tumor cells is just one half of the equation.

  • 2 weeks ago | drugdiscoverynews.com | Stephanie DeMarco

    Whether identifying metabolic dysfunction in a newborn baby or the levels of a drug in a person enrolled in a clinical trial, mass spectrometry can provide a window into how individual molecules pulsing through the body affect health. While mass spectrometry is a very sensitive analytical technique, it is a complex procedure to perform. The traditional mass spectrometry workflow often requires a series of manual and complicated steps to prepare samples before they even reach the mass spectrometer.

  • 3 weeks ago | drugdiscoverynews.com | Stephanie DeMarco

    Backed by patient data and an AI platform, the BPGbio team presented promising results for a mitochondrial-targeted therapy in glioblastoma at AACR 2025. Credit: iStock.com/Sci-MondeBacked by patient data and an AI platform, the BPGbio team presented promising results for a mitochondrial-targeted therapy in glioblastoma at AACR 2025.

  • 3 weeks ago | drugdiscoverynews.com | Stephanie DeMarco

    At the recent American Association for Cancer Research meeting (AACR 2025), we asked cancer researchers working in biotech, pharma, and academia which cancer clinical trials or developments they’re keeping track of. Which cancer clinical developments are you watching closely? Because we're interested in colorectal cancer, specifically microsatellite stable colorectal cancer, we're really curious to see what cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) inhibition will do.

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Stephanie DeMarco, PhD
Stephanie DeMarco, PhD @sci_steph
3 Dec 24

RT @DrugDiscovNews: Whether lost in a 30-year-old data set or a 1,000-year-old leech book, scientists are using new machine learning and AI…

Stephanie DeMarco, PhD
Stephanie DeMarco, PhD @sci_steph
3 Dec 24

RT @DrugDiscovNews: Hepatic stellate cells are most directly responsible for liver fibrosis, but what else is involved? @AndrewSaintsing…

Stephanie DeMarco, PhD
Stephanie DeMarco, PhD @sci_steph
3 Dec 24

RT @DrugDiscovNews: Antidepressants have been used to treat pain, but often take too long to work. @GLopez_924 spoke with scientists @Ica…