Stephanie DeMarco

United States

Managing Editor at DDNews

Articles

New cancer fitness drugs aim to trigger tumor death

1 month ago | drugdiscoverynews.com | Stephanie DeMarco

While oncogenes are notorious for causing cancer when mutated, they are not the only genes that keep cancer alive and spreading. Cancer fitness genes don’t cause cancer, but they help cancer cells avoid death through a variety of different mechanisms including by keeping oncogenes functioning, promoting certain signaling pathways, or sustaining an immunosuppressive environment around the tumor.
Targeting solid tumors two ways with one cancer vaccine

1 month ago | drugdiscoverynews.com | Stephanie DeMarco

In their quest to proliferate and spread, cancer cells will do anything they can to avoid being killed. Most often they develop mechanisms to suppress attacks by their would-be killers — immune cells. One way researchers and clinicians fight back against this suppression is with cancer vaccines that help immune cells recognize and attack cancer cells. But recognizing tumor cells is just one half of the equation.
Making mass spectrometry more accessible with automation

1 month ago | drugdiscoverynews.com | Stephanie DeMarco

Whether identifying metabolic dysfunction in a newborn baby or the levels of a drug in a person enrolled in a clinical trial, mass spectrometry can provide a window into how individual molecules pulsing through the body affect health. While mass spectrometry is a very sensitive analytical technique, it is a complex procedure to perform. The traditional mass spectrometry workflow often requires a series of manual and complicated steps to prepare samples before they even reach the mass spectrometer.
Hope for deadly brain cancers with a mitochondrial drug

1 month ago | drugdiscoverynews.com | Stephanie DeMarco

Backed by patient data and an AI platform, the BPGbio team presented promising results for a mitochondrial-targeted therapy in glioblastoma at AACR 2025. Credit: iStock.com/Sci-MondeBacked by patient data and an AI platform, the BPGbio team presented promising results for a mitochondrial-targeted therapy in glioblastoma at AACR 2025.
Which clinical developments are cancer experts watching closely?

1 month ago | drugdiscoverynews.com | Stephanie DeMarco

At the recent American Association for Cancer Research meeting (AACR 2025), we asked cancer researchers working in biotech, pharma, and academia which cancer clinical trials or developments they’re keeping track of. Which cancer clinical developments are you watching closely? Because we're interested in colorectal cancer, specifically microsatellite stable colorectal cancer, we're really curious to see what cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) inhibition will do.
How turmoil at the NIH is affecting cancer research

1 month ago | drugdiscoverynews.com | Stephanie DeMarco

As more than 20,000 researchers, clinicians, patients, and students from all over the world descended on Chicago for the American Association of Cancer Research (AACR)’s 2025 Annual Meeting, the recent upheaval at the National Institutes of Health (NIH) never seemed far from people’s minds. Over the past few months, delays or outright cancellations of NIH grants and firing of NIH staff have halted critical research.
Letter to the Editor: Road Collapse Incident and Political Concerns in Downe Township

2 months ago | gloucestercitynews.net | Stephanie DeMarco |Dorothy Philbin |Joe Ball

By Stephanie DemarcoA 2024 vehicle accident involving the stepson of Downe Township Mayor Mike Rothman has ignited controversy, as residents question the use of taxpayer funds to settle the matter and demand more transparency from local officials. On June 21, 2024, Nicholas (Nico) Haines was driving along Maple Avenue in the Dividing Creek section of Downe Township when the roadway allegedly collapsed beneath his truck.
Editing precious patient cells in a single drop

2 months ago | drugdiscoverynews.com | Stephanie DeMarco

Genetic screens can give researchers all sorts of insights into how a particular small molecule or drug candidate might act in a given disease. While these kinds of screens work well when scientists are working with a cell type that they can easily culture and expand, their task becomes much harder if they want to perform the same experiments in rare patient cells or cells that are more difficult to culture.
2025 Breakthrough Prizes in Life Sciences announced | Drug Discovery News

2 months ago | drugdiscoverynews.com | Allison Whitten |Stephanie DeMarco |Dika Ojiakor

Advances in GLP-1 research for diabetes and obesity, multiple sclerosis discoveries, and DNA editing are awarded in this year’s prestigious prize.
Overcoming delivery hurdles, IL-12 tackles ovarian cancer

Mar 27, 2025 | drugdiscoverynews.com | Stephanie DeMarco

A targeted interleukin-12 gene therapy plus chemotherapy increased survival in advanced ovarian cancer, setting the stage for a new first-line drug. Credit: iStock.com/koto_fejaA targeted interleukin-12 gene therapy plus chemotherapy increased survival in advanced ovarian cancer, setting the stage for a new first-line drug. | 7 min readStephanie DeMarco, PhDRegister for free to listen to this articleDeep within the abdomen, on either side of the uterus, sit the ovaries.