Stephanie DeMarco

United States

Managing Editor at DDNews

Articles

Which clinical developments are cancer experts watching closely?

3 days ago | drugdiscoverynews.com | Stephanie DeMarco

At the recent American Association for Cancer Research meeting (AACR 2025), we asked cancer researchers working in biotech, pharma, and academia which cancer clinical trials or developments they’re keeping track of. Which cancer clinical developments are you watching closely? Because we're interested in colorectal cancer, specifically microsatellite stable colorectal cancer, we're really curious to see what cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) inhibition will do.
How turmoil at the NIH is affecting cancer research

1 week ago | drugdiscoverynews.com | Stephanie DeMarco

As more than 20,000 researchers, clinicians, patients, and students from all over the world descended on Chicago for the American Association of Cancer Research (AACR)’s 2025 Annual Meeting, the recent upheaval at the National Institutes of Health (NIH) never seemed far from people’s minds. Over the past few months, delays or outright cancellations of NIH grants and firing of NIH staff have halted critical research.
Letter to the Editor: Road Collapse Incident and Political Concerns in Downe Township

2 weeks ago | gloucestercitynews.net | Stephanie DeMarco |Dorothy Philbin |Joe Ball

By Stephanie DemarcoA 2024 vehicle accident involving the stepson of Downe Township Mayor Mike Rothman has ignited controversy, as residents question the use of taxpayer funds to settle the matter and demand more transparency from local officials. On June 21, 2024, Nicholas (Nico) Haines was driving along Maple Avenue in the Dividing Creek section of Downe Township when the roadway allegedly collapsed beneath his truck.
Editing precious patient cells in a single drop

3 weeks ago | drugdiscoverynews.com | Stephanie DeMarco

Genetic screens can give researchers all sorts of insights into how a particular small molecule or drug candidate might act in a given disease. While these kinds of screens work well when scientists are working with a cell type that they can easily culture and expand, their task becomes much harder if they want to perform the same experiments in rare patient cells or cells that are more difficult to culture.
2025 Breakthrough Prizes in Life Sciences announced | Drug Discovery News

1 month ago | drugdiscoverynews.com | Allison Whitten |Stephanie DeMarco |Dika Ojiakor

Advances in GLP-1 research for diabetes and obesity, multiple sclerosis discoveries, and DNA editing are awarded in this year’s prestigious prize.
Overcoming delivery hurdles, IL-12 tackles ovarian cancer

1 month ago | drugdiscoverynews.com | Stephanie DeMarco

A targeted interleukin-12 gene therapy plus chemotherapy increased survival in advanced ovarian cancer, setting the stage for a new first-line drug. Credit: iStock.com/koto_fejaA targeted interleukin-12 gene therapy plus chemotherapy increased survival in advanced ovarian cancer, setting the stage for a new first-line drug. | 7 min readStephanie DeMarco, PhDRegister for free to listen to this articleDeep within the abdomen, on either side of the uterus, sit the ovaries.
Armoring up CAR T cells to fight solid tumors

1 month ago | drugdiscoverynews.com | Stephanie DeMarco

Whether facing down a virus-infected cell or a cancerous one, T cells fight off threats to keep the body healthy. To make these T cells even more effective, particularly in treating blood cancers, scientists created chimeric antigen receptor (CAR) T cells that recognize these cancerous cells by the CD19 marker on their cell surface. So far, the FDA has approved seven different CAR T cell therapies for hematological cancers.
A new drug-device combination for non-hormonal contraception

2 months ago | drugdiscoverynews.com | Stephanie DeMarco

After working on drugs for fibromyalgia and rheumatoid arthritis — both conditions that disproportionately affect women — Sabrina Johnson, now the Chief Executive Officer and President of Daré Bioscience, realized that she wanted to work for a company that developed products specifically for women’s health. But when she went looking for those places, “I was very, very disappointed,” she said.
Editorial: Of snakes and science communication

2 months ago | drugdiscoverynews.com | Stephanie DeMarco

A close encounter with a venomous critter sparked insight for communicating science in times of stress. Credit: iStock.com/Alexander WongA close encounter with a venomous critter sparked insight for communicating science in times of stress. | 3 min readStephanie DeMarco, PhDRegister for free to listen to this articleI like to think that I’m a pretty good communicator.
Amgen drug blocks immune chitchat that drives Sjögren’s disease

2 months ago | drugdiscoverynews.com | Stephanie DeMarco

From dry eyes to what feels like a mouth full of cotton, people with Sjögren’s syndrome deal with irritating and painful symptoms every day. While there are some medications that can treat the symptoms of this autoimmune condition — such as eye drops and steroids — none of these drugs treat the underlying immunological cause of the disease.