Stephen Brown Mayfield

Jul 4, 2024 | biorxiv.org | Martin Valdearcos |Emily McGrath |Andrew K. Folick |Stephen Brown Mayfield

AbstractMammalian glucose homeostasis is, in part, nutritionally programmed during early neonatal life, a critical window for the formation of synapses between hypothalamic glucoregulatory centers. Although microglia are known to prune synapses throughout the brain, their specific role in refining hypothalamic glucoregulatory circuits remains unknown. Here, we show that microglia in the mediobasal hypothalamus (MBH) of mice actively engage in synaptic pruning during early life.