Stephen Christensen

Jul 30, 2024 | nature.com | Joshua Chiou |Saori Sakaue |Stephen Christensen |Soumya Raychaudhuri

AbstractGenetic variation in the human leukocyte antigen (HLA) loci is associated with risk of immune-mediated diseases, but the molecular effects of HLA polymorphism are unclear. Here we examined the effects of HLA genetic variation on the expression of 2940 plasma proteins across 45,330 Europeans in the UK Biobank, with replication analyses across multiple ancestry groups.