Stephen V. Faraone

Aug 5, 2024 | tandfonline.com | Samuele Cortese |David Goodman |Stephen V. Faraone

KEYWORDS: ADHDAttention Deficit Hyperactivity DisorderOlder adultsCognitive declineGeriatrics 1. IntroductionAttention deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition characterized by inappropriate levels of inattention, hyperactivity, and impulsivity, which manifest in various environments [Citation1]. Longitudinal studies show that 60% to 90% of children with ADHD continue to exhibit symptoms and impairments into adulthood [Citation2,Citation3].

Jun 4, 2023 | ncbi.nlm.nih.gov | Stephen V. Faraone |Henrik BW Larsson

Conclusions and future directionsThere can be no doubt that DNA variants in genes or regulatory regions increase the risk for ADHD. In rare cases, a single genetic defect may lead to ADHD in the absence of other DNA variants. We do not know how many of these rare variants exist or if such variants require environmental triggers for ADHD to emerge. It is equally clear that no common DNA variants are necessary and sufficient causes of ADHD.