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4 days ago | 
hemophilianewstoday.com | Steve Bryson
Directly switching from Hemlibra (emicizumab) to Novo Nordisk‘s investigational Mim8 (denecimig) was well tolerated in adults and adolescents with hemophilia A, regardless of whether they had inhibitors or not. That’s according to results from the now-completed Phase 3b FRONTIER5 study (NCT05878938), which assessed the safety of switching between the two preventive therapies without a washout period or a Mim8 loading dose in 61 people 12 years and older with hemophilia .
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5 days ago | 
copdnewstoday.com | Steve Bryson
Digital inhalers that measure and record inhalation data and that can remotely monitor patients may help predict impending chronic obstructive pulmonary disease (COPD) exacerbations, that is, episodes when lung symptoms suddenly worsen. That’s according to data from a Phase 4 observational pilot study (NCT05241288) that followed 40 COPD patients with poor lung function and recurrent exacerbations.
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5 days ago | 
multiplesclerosisnewstoday.com | Steve Bryson
A ketogenic diet — a very low-carbohydrate, high-fat diet — rich in long-chain, saturated fatty acids like those in butter and fatty red meat didn’t reduce optic nerve damage in a mouse model of multiple sclerosis (MS), a study shows. Instead, feeding mice this type of diet before the onset of their disease modestly worsened certain visual impairments.
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5 days ago | 
gaucherdiseasenews.com | Steve Bryson
New Jersey’s newborn screening (NBS) program for Gaucher disease has proven itself effective at identifying many newborns with the condition, allowing for early treatment in some cases, an assessment of the program shows. Still, a high rate of false positives — babies who test positive on screening, but aren’t ultimately diagnosed — and parental refusal to pursue confirmatory testing continue to limit the program’s overall effectiveness, the study’s researchers said.
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5 days ago | 
angioedemanews.com | Steve Bryson
Oral deucrictibant continued to control swelling attacks as a preventative therapy and rapidly stop swelling attacks as an on-demand treatment for hereditary angioedema (HAE), according to new data from the open-label extension portions of two clinical trials. All open-label extension participants said that preventive deucrictibant controlled their HAE attacks, leading to a high level of treatment satisfaction and improved quality of life.
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1 week ago | 
epidermolysisbullosanews.com | Steve Bryson
Treatment with dupilumab, a medicine approved for certain inflammatory disorders, eases itch and disease severity in people with different subtypes of dystrophic epidermolysis bullosa (DEB), a small study suggests. Dupilumab-related benefits seen in a woman before she stopped treatment and got pregnant were mostly maintained throughout her pregnancy and childbirth. Treatment had no impact on conception or on the woman’s health or her infant’s, according to researchers.
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1 week ago | 
parkinsonsnewstoday.com | Steve Bryson
Changes in the bacterial communities in the gut and mouth are associated with cognitive impairment in people with Parkinson’s disease, a study suggests. Some oral bacteria and related virulence factors, such as molecules that help bacteria colonize the body — many of which can trigger a potent inflammatory response — were significantly enriched in the guts of Parkinson’s patients with cognitive impairment.
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1 week ago | 
buff.ly | Steve Bryson
Changes in the bacterial communities in the gut and mouth are associated with cognitive impairment in people with Parkinson’s disease, a study suggests. Some oral bacteria and related virulence factors, such as molecules that help bacteria colonize the body — many of which can trigger a potent inflammatory response — were significantly enriched in the guts of Parkinson’s patients with cognitive impairment.
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1 week ago | 
rettsyndromenews.com | Steve Bryson
Changes in auditory event-related potentials, or AEPs, the brain’s electrical activity in response to sound, may serve as a non-invasive biomarker to assess treatment response in people with Rett syndrome, a study suggested. Depressed AEPs, as measured by electroencephalography (EEG), which detects the brain’s electrical activity, were normalized when Rett mice were treated with a molecule that improved multiple features of Rett, the data showed.
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1 week ago | 
multiplesclerosisnewstoday.com | Steve Bryson
Gum disease caused by the bacterium Porphyromonas gingivalis (Pg) is associated with worse multiple sclerosis (MS) in a mouse model of the disease, a study shows. Infection with Pg directly or indirectly boosted pro-inflammatory pathways in immune cells in the spleen, where they’re produced, thereby aggravating MS. These effects were also associated with low oxygen conditions (hypoxia) and the activation of hypoxia-inducible factor 1 alpha (HIF-1-alpha).
