Steven A. Lubitz

Jan 2, 2025 | nature.com | Steven A. Lubitz

AbstractTo broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respectively.

Jan 1, 2025 | jacc.org | Daniel E. Singer |Steven J. Atlas |Alan S. Go |Steven A. Lubitz

Introduction Recent trials of one-time brief electrocardiographic (ECG) screening for atrial fibrillation (AF) have not shown a significant increase in diagnosed AF compared to usual care.1–3 By contrast, longer-term continuous ECG monitoring detected substantially more AF cases, primarily paroxysmal atrial fibrillation (PAF).4-7 By identifying and treating AF earlier, the goal of screening is to reduce the risk of future cardiovascular events, primarily ischemic stroke.8,9 Although the...