Stijn Hentzen

Jun 29, 2023 | onlinelibrary.wiley.com | Tomer Meirson |Kelly Koehn |Aaron Goodman |Stijn Hentzen

Abstract Objectives Patients with multiple myeloma (MM) enrolled in randomized control trials (RCTs) discontinue treatment for various reasons; however, no prior study has analyzed reasons for discontinuation. We performed a systematic review of MM RCTs to investigate reasons for treatment discontinuation, imbalances between trial cohorts, and reporting practices. Methods A comprehensive search for RCTs in MM from 2015 to 2021 identified 45 studies meeting inclusion criteria.