Stuart Oldham

Aug 6, 2024 | biorxiv.org | Ashlea Segal |Robert Smith |Sidhant Chopra |Stuart Oldham

AbstractBackground: Interindividual variability in neurobiological and clinical characteristics in mental illness is often overlooked by classical group mean case control studies. Studies using normative modelling to infer person specific deviations of grey matter volume have indicated that group means are not representative of most individuals. The extent to which this variability is present in white matter morphometry, which is integral to brain function, remains unclear.

Sep 27, 2023 | nature.com | Stuart Oldham

AbstractThe thalamus enables key sensory, motor, emotive, and cognitive processes via connections to the cortex. These projection patterns are traditionally considered to originate from discrete thalamic nuclei, however recent work showing gradients of molecular and connectivity features in the thalamus suggests the organisation of thalamocortical connections occurs along a continuous dimension.

Apr 10, 2023 | biologicalpsychiatryjournal.com | Sidhant Chopra |Stuart Oldham |Alex Holmes |Ashlea Segal

Different regions of the brain’s grey matter are connected by a complex network of white-matter fibres, which are responsible for the propagation of action potentials and the transport of trophic and other molecules. In neurodegenerative disease, these connections constrain the way in which grey-matter volume (GMV) abnormalities progress. Here we investigated whether connectome architecture also shapes the spatial pattern of GMV abnormalities across multiple stages of psychotic illness.