
Sucharita Sarkar
Articles
-
3 weeks ago |
cell.com | Sucharita Sarkar |Ian MacRae |Ian Macrae
Get full text accessLog in, subscribe or purchase for full access. References1. Bobadilla Ugarte, P. ∙ Halter, S. ∙ Mutte, S.K. ... Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNAMol. Cell. 2025; 85:1920-1937.e102. Bernstein, E. ∙ Caudy, A.A. ∙ Hammond, S.M. ... Role for a bidentate ribonuclease in the initiation step of RNA interferenceNature. 2001; 409:363-3663. Zamore, P.D. ∙ Tuschl, T. ∙ Sharp, P.A. ...
-
Dec 6, 2024 |
biorxiv.org | Sucharita Sarkar |Ian MacRae |Ian Macrae
AbstractSmall interfering RNAs (siRNAs) guide mRNA cleavage by human Argonaute2 (hAgo2), leading to targeted gene silencing. Despite their laboratory and clinical impact, structural insights into human siRNA catalytic activity remain elusive. Here, we show that disrupting siRNA 3'end binding by hAgo2 accelerates target cleavage and stabilizes its catalytic conformation, enabling detailed structural analysis.
Try JournoFinder For Free
Search and contact over 1M+ journalist profiles, browse 100M+ articles, and unlock powerful PR tools.
Start Your 7-Day Free Trial →